Xingyi (Daniel) Chen

I am Xingyi (Daniel) Chen, a rising senior at Johns Hopkins University studying Applied Mathematics & Statistics with minors in Computational Medicine and Mathematics.

My interests lie in biostatistics, computational genomics, and biomedical data science, especially in developing statistical and machine learning methods for high-dimensional biomedical data. I am particularly interested in single-cell and spatial genomics, transcriptomics, and translational problems in medicine and healthcare.

For Summer 2026, I will be a full-time QSURE intern at Memorial Sloan Kettering Cancer Center (MSKCC) in Manhattan, New York. I will work under Dr. Andrew McPherson.

I am currently a research assistant in the Hicks Lab, where I develop computational methods and reproducible pipelines for spatial transcriptomics and RNA-seq analysis. My recent work includes building Visium HD analysis workflows, porting SpotSweeper from R to Python and releasing a Python implementation (GitHub, PyPI), developing isoform-level models for biological age prediction, and maintaining the Python package visiumhd-utils.

Previously, I worked in the Beer Lab at Johns Hopkins on exploratory analysis and visualization of gene expression data, and I completed a bioinformatics internship in the Wei Lab, where I supported spatial-omics projects and presented literature reviews on machine learning applications in genomics.

I am broadly interested in pursuing PhD training at the intersection of biostatistics, statistical genomics, and computational biology.

Outside of research, I enjoy traveling, exploring new cafes/restaurants/cities, and having fun with my friends :)

You can find my CV, GitHub, LinkedIn, and other links below.

selected publications

PhysRev

Can Quantum-Mechanical Description of Physical Reality Be Considered Complete?

A. Einstein^*†, B. Podolsky^*, and N. Rosen^*

Phys. Rev., New Jersey. More Information can be found here , May 1935

Abs DOI HTML PDF Video

In a complete theory there is an element corresponding to each element of reality. A sufficient condition for the reality of a physical quantity is the possibility of predicting it with certainty, without disturbing the system. In quantum mechanics in the case of two physical quantities described by non-commuting operators, the knowledge of one precludes the knowledge of the other. Then either (1) the description of reality given by the wave function in quantum mechanics is not complete or (2) these two quantities cannot have simultaneous reality. Consideration of the problem of making predictions concerning a system on the basis of measurements made on another system that had previously interacted with it leads to the result that if (1) is false then (2) is also false. One is thus led to conclude that the description of reality as given by a wave function is not complete.